Fluorescent vinblastine probes for live cell imaging | Zendy

Labros G. Meimetis | Zendy; Randy J. Giedt | Zendy; Hannes Mikula | Zendy; Jonathan Carlson | Zendy; Rainer H. Köhler | Zendy; David B. Pirovich | Zendy; Ralph Weissleder | Zendy

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Fluorescent vinblastine probes for live cell imaging

Author(s) -

Labros G. Meimetis,

Randy J. Giedt,

Hannes Mikula,

Jonathan Carlson,

Rainer H. Köhler,

David B. Pirovich,

Ralph Weissleder

Publication year - 2016

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c6cc04129a

Subject(s) - vinblastine , fluorescence , antimitotic agent , live cell imaging , microtubule , chemistry , fluorescence lifetime imaging microscopy , imaging agent , biophysics , cell , combinatorial chemistry , tubulin , microbiology and biotechnology , biology , biochemistry , chemotherapy , physics , in vivo , optics , genetics

Herein we describe the synthesis of several fluorescent analogues of the clinically approved microtubule destabilizing agent vinblastine. The evaluated probes are the most potent described and provides the first example of uptake, distribution and live cell imaging using this well known antimitotic agent.

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