Cisplatin nephrotoxicity in male beagle dogs: next-generation protein kidney safety biomarker tissue expression and related changes in urine | Zendy

J. Eric McDuffie | Zendy; Y. Chen | Zendy; J. Y. | Zendy; S. Lee | Zendy; Karen Lynch | Zendy; D. M. Hamlin | Zendy; Linh T. Nguyen | Zendy; Michèle Rizzolio | Zendy; Manisha Sonee | Zendy; Sandra S. Snook | Zendy

Open Access

Cisplatin nephrotoxicity in male beagle dogs: next-generation protein kidney safety biomarker tissue expression and related changes in urine

Author(s) -

J. Eric McDuffie,

Y. Chen,

J. Y.,

S. Lee,

Karen Lynch,

D. M. Hamlin,

Linh T. Nguyen,

Michèle Rizzolio,

Manisha Sonee,

Sandra S. Snook

Publication year - 2016

Publication title -

toxicology research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.709

H-Index - 31

eISSN - 2045-4538

pISSN - 2045-452X

DOI - 10.1039/c5tx00497g

Subject(s) - clusterin , beagle , urine , medicine , nephrotoxicity , biomarker , kidney , urinary system , cisplatin , pathology , lipocalin , staining , urology , apoptosis , biology , chemotherapy , biochemistry

In dogs, CDDP induced corticomedullary tubular lesions [A.]; clusterin (CLU) staining in damaged medullary tubules [B.]; and elevated urinary CLU [C.]. Baseline CLU was detected from Control dogs [A. and C.].

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