Open AccessIn vitro toxicological evaluation of ethyl carbamate in human HepG2 cells
Author(s) -
Cui Xia,
Jiayi Wang,
Nannan Qiu,
Yongning Wu
Publication year - 2016
Publication title -
toxicology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.709
H-Index - 31
eISSN - 2045-4538
pISSN - 2045-452X
DOI - 10.1039/c5tx00453e
Subject(s) - carbamate , cytotoxic t cell , oxidative stress , in vitro , apoptosis , ethyl carbamate , chemistry , viability assay , necrosis , pharmacology , microbiology and biotechnology , biochemistry , biology , food science , wine , genetics
Ethyl carbamate could decrease the viability of HepG2 cells by arresting the cell cycle in the G1 phase, as well as apoptosis and necrosis. Moreover, an oxidative stress mechanism also contributed to the cytotoxic effects of EC.
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