The binary, ternary and quaternary mixture toxicity of benzo[a]pyrene, arsenic, cadmium and lead in HepG2 cells
Author(s) -
Sasikumar Muthusamy,
Cheng Peng,
J. C. Ng
Publication year - 2016
Publication title -
toxicology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.709
H-Index - 31
eISSN - 2045-4538
pISSN - 2045-452X
DOI - 10.1039/c5tx00425j
Subject(s) - pyrene , chemistry , cadmium , arsenic , benzo(a)pyrene , ternary operation , environmental chemistry , metal , antagonism , toxicity , toxicant , metal toxicity , cytotoxicity , genotoxicity , nuclear chemistry , chromatography , organic chemistry , biochemistry , in vitro , receptor , computer science , programming language
The toxicity of multi-component mixtures of B[ a ]P and heavy metal/loid(s) was determined in HepG2 cells. Concentration dependent synergism, additivity or antagonism was predicted by the combination-index isobologram method.
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