Genome-wide transcriptional analysis of silica nanoparticle-induced toxicity in zebrafish embryos | Zendy

Hejing Hu | Zendy; Qiuling Li | Zendy; Lizhen Jiang | Zendy; Yang Zou | Zendy; Junchao Duan | Zendy; Zhiwei Sun | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Genome-wide transcriptional analysis of silica nanoparticle-induced toxicity in zebrafish embryos

Author(s) -

Hejing Hu,

Qiuling Li,

Lizhen Jiang,

Yang Zou,

Junchao Duan,

Zhiwei Sun

Publication year - 2016

Publication title -

toxicology research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.709

H-Index - 31

eISSN - 2045-4538

pISSN - 2045-452X

DOI - 10.1039/c5tx00383k

Subject(s) - zebrafish , signal transduction , toxicity , microbiology and biotechnology , embryo , biology , apoptosis , metabolic pathway , mapk/erk pathway , biological pathway , gene , gene expression , chemistry , genetics , organic chemistry

Silica nanoparticle-induced toxicity in zebrafish embryos affected expression of 2515 genes. Pathway analysis and Signal-net analysis indicated that the gap junction, vascular smooth muscle contraction, and metabolic pathways, apoptosis, the MAPK signaling pathway, the calcium signaling pathway and the JAK-STAT signaling pathway were the most prominent significant pathways in SiNP-induced toxicity in zebrafish embryos.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research