Open AccessThe influence of the SULT1A status – wild-type, knockout or humanized – on the DNA adduct formation by methyleugenol in extrahepatic tissues of mice
Author(s) -
Kristin Herrmann,
Wolfram Engst,
Simone Florian,
Alfonso Lampen,
Walter Meinl,
Hansruedi Glatt
Publication year - 2016
Publication title -
toxicology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.709
H-Index - 31
eISSN - 2045-4538
pISSN - 2045-452X
DOI - 10.1039/c5tx00358j
Subject(s) - adduct , sulfotransferase , dna adduct , chemistry , kidney , caecum , carcinogen , knockout mouse , spleen , medicine , endocrinology , biochemistry , enzyme , microbiology and biotechnology , biology , gene , organic chemistry
DNA adduction by methyleugenol was nearly fully dependent on the expression of SULT1A enzymes in mouse liver, caecum and kidney. It was independent of SULT1A in stomach.
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