Open AccessGenotoxic risk of quinocetone and its possible mechanism in in vitro studies
Author(s) -
Xu Wang,
Panpan Yang,
Juan Li,
Awais Ihsan,
Qianying Liu,
Guyue Cheng,
Yanfei Tao,
Zhengli Liu,
Zonghui Yuan
Publication year - 2015
Publication title -
toxicology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.709
H-Index - 31
eISSN - 2045-4538
pISSN - 2045-452X
DOI - 10.1039/c5tx00341e
Subject(s) - genotoxicity , dna damage , dna , topoisomerase , chemistry , comet assay , mutagen , guanine , reactive oxygen species , biochemistry , 8 hydroxy 2' deoxyguanosine , mitochondrial dna , microbiology and biotechnology , biology , gene , dna oxidation , toxicity , nucleotide , organic chemistry
Quinocetone possessing the quinoxaline-1,4-dioxide basic structure is used for its antibacterial action, although its mechanism of genotoxicity is not clear.
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