Open AccessIncreased expression of bone morphogenetic protein-7 and its related pathway provides an anti-fibrotic effect on silica induced fibrosis in vitro
Author(s) -
Di Liang,
Yan Wang,
Zhonghui Zhu,
Gengxia Yang,
Guoliang An,
Xiaoli Li,
Piye Niu,
Li Chen,
Lin Tian
Publication year - 2015
Publication title -
toxicology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.709
H-Index - 31
eISSN - 2045-4538
pISSN - 2045-452X
DOI - 10.1039/c5tx00159e
Subject(s) - in vitro , microbiology and biotechnology , fibrosis , bone morphogenetic protein , bone morphogenetic protein 2 , bone morphogenetic protein 7 , signal transduction , chemistry , secretion , protein expression , cancer research , biology , biochemistry , medicine , gene
BMP-7 exerts an inhibitory effect on silica induced fibrosis in RLE-6TN cells via suppressing TGF-β signaling and activating BMP signaling.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom