Open AccessTCF7L2 activation is required for myelin regeneration in 5-FU-induced demyelinating mice
Author(s) -
Biqin Tan,
Jing Wang,
Mengting Zhao,
Yan Hu,
Jiajia Wang,
Bo Yang,
Qiaojun He,
Xiao Yang,
Qinjie Weng
Publication year - 2015
Publication title -
toxicology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.709
H-Index - 31
eISSN - 2045-4538
pISSN - 2045-452X
DOI - 10.1039/c5tx00110b
Subject(s) - myelin , regeneration (biology) , oligodendrocyte , degeneration (medical) , medicine , neuroscience , microbiology and biotechnology , cancer research , biology , pathology , central nervous system
Previous studies have shown that 5-FU (5-fluorouracil) could cause delayed myelin degeneration by inducing oligodendrocyte death.
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