Open AccessAutophagy as the effector and player in DNA damage response of cells to genotoxicants
Author(s) -
Shi-Meng Zhang,
Zeng-Fu Shang,
PingKun Zhou
Publication year - 2015
Publication title -
toxicology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.709
H-Index - 31
eISSN - 2045-4538
pISSN - 2045-452X
DOI - 10.1039/c5tx00043b
Subject(s) - autophagy , dna damage , effector , microbiology and biotechnology , mechanism (biology) , dna , biology , dna repair , computational biology , chemistry , genetics , apoptosis , philosophy , epistemology
In this review, we provide an overview and discuss the molecular mechanism of DNA damage induced autophagy, and their mutual regulation and its role in cell fate determination in response to genotoxic effects of environmental toxicants.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom