Open AccessPrenatal nicotine exposure induced GDNF/c-Ret pathway repression-related fetal renal dysplasia and adult glomerulosclerosis in male offspring
Author(s) -
Zhaoxia Sun,
Shuangshuang Hu,
Na Zuo,
Shuailong Yang,
Zheng He,
Ying Ao,
Hui Wang
Publication year - 2015
Publication title -
toxicology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.709
H-Index - 31
eISSN - 2045-4538
pISSN - 2045-452X
DOI - 10.1039/c5tx00040h
Subject(s) - offspring , glomerulosclerosis , medicine , endocrinology , fetus , dysplasia , nicotine , pregnancy , physiology , kidney , biology , proteinuria , genetics
Prenatal nicotine exposure could induce fetal renal dysplasia associated with the suppression of the GDNF/c-Ret pathway and adult glomerulosclerosis in male offspring, which might be mediated by alterations in angiotensin II receptors.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom