One-pot synthesis of 2,3-substituted benzo[b]thiophenes via Cu(i) catalysed intramolecular cyclisation from dithioesters | Zendy

Nagarakere C. Sandhya | Zendy; Kebbahalli N. Nandeesh | Zendy; Kanchugarakoppal S. Rangappa | Zendy; Sannaiah Ananda | Zendy

Open Access

One-pot synthesis of 2,3-substituted benzo[b]thiophenes via Cu(i) catalysed intramolecular cyclisation from dithioesters

Author(s) -

Nagarakere C. Sandhya,

Kebbahalli N. Nandeesh,

Kanchugarakoppal S. Rangappa,

Sannaiah Ananda

Publication year - 2015

Publication title -

rsc advances

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.746

H-Index - 148

ISSN - 2046-2069

DOI - 10.1039/c5ra02114f

Subject(s) - intramolecular force , chemistry , catalysis , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry

Efficient synthesis of benzo[b]thiophenes from o-halophenyl acetonitrile has been achieved. This novel one-pot procedure involves CuI and pivalic acid catalyzed C-S bond formation using dithioesters followed by a heterocyclization reaction. This efficient protocol has the advantages of one-pot synthesis, short reaction time, good yields (62-78%) and operational simplicity

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