Synthesis and evaluation of the biological activity of N′-[2-oxo-1,2 dihydro-3H-indol-3-ylidene] benzohydrazides as potential anticancer agents | Zendy

Arpit Katiyar | Zendy; Mahesh Hegde | Zendy; Sujeet Kumar | Zendy; Vidya Gopalakrishnan | Zendy; Khyati Bhatelia | Zendy; Kavya Ananthaswamy | Zendy; Sureshbabu A. Ramareddy | Zendy; Erik De Clercq | Zendy; Bibha Choudhary | Zendy; Dominique Schols | Zendy; Sathees C. Raghavan | Zendy; Subhas S. Karki | Zendy

Open Access

Synthesis and evaluation of the biological activity of N′-[2-oxo-1,2 dihydro-3H-indol-3-ylidene] benzohydrazides as potential anticancer agents

Author(s) -

Arpit Katiyar,

Mahesh Hegde,

Sujeet Kumar,

Vidya Gopalakrishnan,

Khyati Bhatelia,

Kavya Ananthaswamy,

Sureshbabu A. Ramareddy,

Erik De Clercq,

Bibha Choudhary,

Dominique Schols,

Sathees C. Raghavan,

Subhas S. Karki

Publication year - 2015

Publication title -

rsc advances

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.746

H-Index - 148

ISSN - 2046-2069

DOI - 10.1039/c5ra01528f

Subject(s) - chemistry , combinatorial chemistry , stereochemistry , medicinal chemistry

New N'-2-oxo-1,2-dihydro-3H-indol-3-ylidene]benzohydrazide derivatives were synthesized and evaluated for their cytotoxic properties against murine leukemia, L1210, human leukemia, REH and K562, human T-cell leukemia, CEM and human cervix carcinoma, HeLa cells. Among the tested compounds, the 3,4,5-trimethoxy-N'-5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]ben zohydrazide derivative (5t) emerged as the most potent inhibitor against all the tumor cell lines evaluated. To investigate the mechanism of action, 5t was further studied by cell cycle analysis, mitochondrial membrane potential analysis, DNA fragmentation and Annexin V-FITC flow cytometric analysis, which suggested that 5t was able to induce apoptosis at submicromolar range

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