Enzymatically degradable hybrid organic–inorganic bridged silsesquioxane nanoparticles for in vitro imaging | Zendy

Yevhen Fatieiev | Zendy; Jonas G. Croissant | Zendy; Khachatur Julfakyan | Zendy; Lin Deng | Zendy; Dalaver H. Anjum | Zendy; Andrei Gurinov | Zendy; Niveen M. Khashab | Zendy

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Enzymatically degradable hybrid organic–inorganic bridged silsesquioxane nanoparticles for in vitro imaging

Author(s) -

Yevhen Fatieiev,

Jonas G. Croissant,

Khachatur Julfakyan,

Lin Deng,

Dalaver H. Anjum,

Andrei Gurinov,

Niveen M. Khashab

Publication year - 2015

Publication title -

nanoscale

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.038

H-Index - 224

eISSN - 2040-3372

pISSN - 2040-3364

DOI - 10.1039/c5nr03065j

Subject(s) - silsesquioxane , nanoparticle , dispersity , nanomaterials , materials science , nanotechnology , polymer , chemical engineering , polymer chemistry , composite material , engineering

We describe biodegradable bridged silsesquioxane (BS) composite nanomaterials with an unusually high organic content (ca. 50%) based on oxamide components mimicking amino acid biocleavable groups. Unlike most bulk BS materials, the design of sub-200 nm nearly monodisperse nanoparticles (NPs) was achieved. These enzymatically degradable BS NPs were further tested as promising imaging nanoprobes.

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