Transactivation of the human retinoid X receptor by organotins: use of site-directed mutagenesis to identify critical amino acid residues for organotin-induced transactivation | Zendy

Youhei Hiromori | Zendy; Akira Aoki | Zendy; Junichi Nishikawa | Zendy; Hisamitsu Nagase | Zendy; Tsuyoshi Nakanishi | Zendy

Open Access

Transactivation of the human retinoid X receptor by organotins: use of site-directed mutagenesis to identify critical amino acid residues for organotin-induced transactivation

Author(s) -

Youhei Hiromori,

Akira Aoki,

Junichi Nishikawa,

Hisamitsu Nagase,

Tsuyoshi Nakanishi

Publication year - 2015

Publication title -

metallomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.012

H-Index - 75

eISSN - 1756-591X

pISSN - 1756-5901

DOI - 10.1039/c5mt00086f

Subject(s) - transactivation , retinoid x receptor , chemistry , mutant , biochemistry , retinoid x receptor alpha , peroxisome proliferator activated receptor , amino acid , receptor , nuclear receptor , retinoid , retinoic acid , gene , transcription factor

Organotins, such as tributyltin (TBT) and triphenyltin (TPT), may disrupt endocrine activity in mammals arising from their ability to act as ligands for the retinoid X receptor (RXR) and the peroxisome proliferator-activated receptor γ (PPARγ).

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