Catalytic defluorinative [3 + 2] cycloaddition of trifluoromethylalkenes with alkynes via reduction of nickel(ii) fluoride species | Zendy

Takeshi Fujita | Zendy; Tomohiro Arita | Zendy; Tomohiro Ichitsuka | Zendy; Junji Ichikawa | Zendy

Open Access

Catalytic defluorinative [3 + 2] cycloaddition of trifluoromethylalkenes with alkynes via reduction of nickel(ii) fluoride species

Author(s) -

Takeshi Fujita,

Tomohiro Arita,

Tomohiro Ichitsuka,

Junji Ichikawa

Publication year - 2015

Publication title -

dalton transactions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.98

H-Index - 184

eISSN - 1477-9234

pISSN - 1477-9226

DOI - 10.1039/c5dt02160j

Subject(s) - nickel , cycloaddition , catalysis , fluoride , chemistry , domino , fluorine , trifluoromethyl , medicinal chemistry , combinatorial chemistry , organic chemistry , inorganic chemistry , alkyl

Nickel-catalyzed [3 + 2] cycloaddition of 2-trifluoromethyl-1-alkenes with alkynes via domino C-F bond activation was achieved by sequential β-fluorine elimination. The nickel(ii) fluoride species formed in this reaction was reduced by a diboron compound, regenerating the catalytically active nickel(0) species.

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