A no observed adverse effect level for DNA adduct formation in rat liver with prolonged dosing of the hepatocarcinogen 2-acetylaminofluorene | Zendy

Gary M. Williams | Zendy; JianDong Duan | Zendy; Michael J. Iatropoulos | Zendy; Tetyana Kobets | Zendy

Open Access

A no observed adverse effect level for DNA adduct formation in rat liver with prolonged dosing of the hepatocarcinogen 2-acetylaminofluorene

Author(s) -

Gary M. Williams,

JianDong Duan,

Michael J. Iatropoulos,

Tetyana Kobets

Publication year - 2014

Publication title -

toxicology research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.709

H-Index - 31

eISSN - 2045-4538

pISSN - 2045-452X

DOI - 10.1039/c4tx00126e

Subject(s) - 2 acetylaminofluorene , adduct , dosing , dna , chemistry , carcinogen , adverse effect , pharmacology , endocrinology , medicine , cancer , biochemistry , enzyme , organic chemistry , microsome

Administration of AAF by gavage to male rats resulted in formation of several DNA adducts in liver, the pattern of which changed over time and with repair. The cumulative dose of 0.125 mg kg −1 AAF achieved in repeated doses for 16 weeks was a NOAEL for DNA adducts.

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