Manipulating directional cell motility using intracellular superparamagnetic nanoparticles | Zendy

Michael Bradshaw | Zendy; Tristan D. Clemons | Zendy; Diwei Ho | Zendy; Lucía Gutiérrez | Zendy; F. J. Lázaro | Zendy; Michael J. House | Zendy; Timothy G. St. Pierre | Zendy; Mark W. Fear | Zendy; Fiona M. Wood | Zendy; K. Swaminathan Iyer | Zendy

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Manipulating directional cell motility using intracellular superparamagnetic nanoparticles

Author(s) -

Michael Bradshaw,

Tristan D. Clemons,

Diwei Ho,

Lucía Gutiérrez,

F. J. Lázaro,

Michael J. House,

Timothy G. St. Pierre,

Mark W. Fear,

Fiona M. Wood,

K. Swaminathan Iyer

Publication year - 2015

Publication title -

nanoscale

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.038

H-Index - 224

eISSN - 2040-3372

pISSN - 2040-3364

DOI - 10.1039/c4nr06594h

Subject(s) - intracellular , motility , superparamagnetism , nanoparticle , magnetic nanoparticles , biophysics , nanotechnology , cell , materials science , microbiology and biotechnology , chemistry , biochemistry , magnetization , biology , magnetic field , physics , quantum mechanics

This study investigated the ability for magnetic nanoparticles to influence cellular migration in the presence of an external magnetic field. We found that the direction of migrating keratinocytes can be controlled and the migration speed of fibroblasts can be increased with the internalisation of these nanoparticles in the presence of a magnetic field. The possibility of shepherding cells towards a region of interest through the use of internalized nanoparticles is an attractive prospect for cell tracking, cell therapies, and tissue engineering applications.

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