The English (H6R) familial Alzheimer's disease mutation facilitates zinc-induced dimerization of the amyloid-β metal-binding domain | Zendy

Sergey A. Kozin | Zendy; Alexandra A. Kulikova | Zendy; Andrei Istrate | Zendy; Philipp O. Tsvetkov | Zendy; Sergey S. Zhokhov | Zendy; Yuri V. Mezentsev | Zendy; O. I. Kechko | Zendy; Ivanov As | Zendy; Vladimir I. Polshakov | Zendy; Alexander Makarov | Zendy

Open Access

The English (H6R) familial Alzheimer's disease mutation facilitates zinc-induced dimerization of the amyloid-β metal-binding domain

Author(s) -

Sergey A. Kozin,

Alexandra A. Kulikova,

Andrei Istrate,

Philipp O. Tsvetkov,

Sergey S. Zhokhov,

Yuri V. Mezentsev,

O. I. Kechko,

Ivanov As,

Vladimir I. Polshakov,

Alexander Makarov

Publication year - 2015

Publication title -

metallomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.012

H-Index - 75

eISSN - 1756-591X

pISSN - 1756-5901

DOI - 10.1039/c4mt00259h

Subject(s) - amyloid (mycology) , zinc , mutation , chemistry , metal , biophysics , biochemistry , biology , gene , inorganic chemistry , organic chemistry

Interaction of Zn(2+) with the metal-binding domain of the English (H6R) amyloid-β mutant results in the formation of peptide dimers. The mutation causes the exclusion of His6 from the zinc chelation pattern observed in the intact domain and triggers the assembly of the dimers via zinc ions coordinated by (11)EVHH(14) fragments.

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