Lab on a chip for continuous-flow magnetic cell separation | Zendy

Majid Hejazian | Zendy; Weihua Li | Zendy; NamTrung Nguyen | Zendy

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Lab on a chip for continuous-flow magnetic cell separation

Author(s) -

Majid Hejazian,

Weihua Li,

NamTrung Nguyen

Publication year - 2014

Publication title -

lab on a chip

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.064

H-Index - 210

eISSN - 1473-0197

pISSN - 1473-0189

DOI - 10.1039/c4lc01422g

Subject(s) - lab on a chip , chip , magnetic bead , magnetic separation , separation (statistics) , continuous flow , flow (mathematics) , materials science , chemistry , microfluidics , chromatography , nanotechnology , computer science , engineering , physics , mechanics , electrical engineering , metallurgy , machine learning

Separation of cells is a key application area of lab-on-a-chip (LOC) devices. Among the various methods, magnetic separation of cells utilizing microfluidic devices offers the merits of biocompatibility, efficiency, and simplicity. This review discusses the fundamental physics involved in using magnetic force to separate particles, and identifies the optimisation parameters and corresponding methods for increasing the magnetic force. The paper then elaborates the design considerations of LOC devices for continuous-flow magnetic cell separation. Examples from the recently published literature illustrate these state-of-the-art techniques.

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