Open AccessA multi-scale approach to designing therapeutics for tuberculosis
Author(s) -
Jennifer J. Linderman,
Nicholas A. Cilfone,
Elsje Pienaar,
Chang Gong,
Denise E. Kirschner
Publication year - 2015
Publication title -
integrative biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 70
eISSN - 1757-9708
pISSN - 1757-9694
DOI - 10.1039/c4ib00295d
Subject(s) - tuberculosis , mycobacterium tuberculosis , immune system , in vivo , immunology , population , biology , medicine , computational biology , microbiology and biotechnology , pathology , environmental health
Approximately one third of the world's population is infected with Mycobacterium tuberculosis. Limited information about how the immune system fights M. tuberculosis and what constitutes protection from the bacteria impact our ability to develop effective therapies for tuberculosis. We present an in vivo systems biology approach that integrates data from multiple model systems and over multiple length and time scales into a comprehensive multi-scale and multi-compartment view of the in vivo immune response to M. tuberculosis. We describe computational models that can be used to study (a) immunomodulation with the cytokines tumor necrosis factor and interleukin 10, (b) oral and inhaled antibiotics, and