Open AccessPd-Catalyzed direct C–H functionalization of imidazolones with aryl- and alkenyl halides
Author(s) -
Mickaël Muselli,
Christine Baudequin,
Christophe Hoarau,
Laurent Bischoff
Publication year - 2014
Publication title -
chemical communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.837
H-Index - 333
eISSN - 1364-548X
pISSN - 1359-7345
DOI - 10.1039/c4cc07917e
Subject(s) - halide , catalysis , aryl , palladium , chemistry , surface modification , copper , combinatorial chemistry , organic chemistry , alkyl
Direct C-H arylation and alkenylation of 4,4'-dialkylimidazolones with a broad range of halides under palladium and copper catalysis have been developed. This methodology is applied to the preparation of recently discovered fatty acid synthetase (FAS) inhibitors.
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