Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences | Zendy

Alex Cousins | Zendy; Dougal J. Ritson | Zendy; Pallavi Sharma | Zendy; Malcolm F. G. Stevens | Zendy; John E. Moses | Zendy; Mark S. Searle | Zendy

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Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences

Author(s) -

Alex Cousins,

Dougal J. Ritson,

Pallavi Sharma,

Malcolm F. G. Stevens,

John E. Moses,

Mark S. Searle

Publication year - 2014

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c4cc07487d

Subject(s) - tandem , g quadruplex , dna , chemistry , selectivity , ligand (biochemistry) , combinatorial chemistry , structural motif , stereochemistry , computational biology , biology , biochemistry , materials science , receptor , catalysis , composite material

Biophysical studies of ligand interactions with three human telomeric repeat sequences (d(AGGG(TTAGGG)n, n = 3, 7 and 11)) show that an oxazole-based 'click' ligand, which induces parallel folded quadruplexes, preferentially stabilises longer telomeric repeats providing evidence for selectivity in binding at the interface between tandem quadruplex motifs.

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