Red Si–rhodamine drug conjugates enable imaging in GFP cells | Zendy

Eunha Kim | Zendy; Katherine S. Yang | Zendy; Randy J. Giedt | Zendy; Ralph Weissleder | Zendy

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Red Si–rhodamine drug conjugates enable imaging in GFP cells

Author(s) -

Eunha Kim,

Katherine S. Yang,

Randy J. Giedt,

Ralph Weissleder

Publication year - 2014

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c4cc00144c

Subject(s) - rhodamine , conjugate , rhodamine 123 , green fluorescent protein , rhodamine b , fluorescence , derivative (finance) , drug , chemistry , intracellular , biophysics , combinatorial chemistry , biochemistry , biology , pharmacology , physics , optics , mathematical analysis , mathematics , photocatalysis , multiple drug resistance , financial economics , economics , catalysis , gene , antibiotics

Here we evaluated a series of Si-derivatized rhodamine (SiR) dyes for their ability to visualize a model drug in live cells. We show that a charge neutral SiR derivative (but not others) can indeed be used to follow the intracellular location of the model therapeutic drug in GFP cells.

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