Open AccessOrganocatalyzed coupling of indoles with dehydroalanine esters: synthesis of bis(indolyl)propanoates and indolacrylates
Author(s) -
Simone Lucarini,
Michele Mari,
Giovanni Piersanti,
Gilberto Spadoni
Publication year - 2013
Publication title -
rsc advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.746
H-Index - 148
ISSN - 2046-2069
DOI - 10.1039/c3ra42922a
Subject(s) - dehydroalanine , chemistry , yield (engineering) , catalysis , indole test , organic chemistry , combinatorial chemistry , amino acid , biochemistry , materials science , metallurgy
Functionalized and substituted bis(indolyl)alkanes were synthesized from indoles and dehydroalanine esters in the presence of catalytic amounts of Brønsted acid. When 2- or 4-bulky substituted indoles were used, unusual elimination occurred to yield interesting indolyl acrylates
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