Open AccessDiscovery of novel pyridazinylthioacetamides as potent HIV-1 NNRTIs using a structure-based bioisosterism approach
Author(s) -
Yuning Song,
Peng Zhan,
Dongwei Kang,
Xiao Li,
Ye Tian,
Zhenyu Li,
Xuwang Chen,
WenMing Chen,
Christophe Pannecouque,
Erik De Clercq,
Xinyong Liu
Publication year - 2013
Publication title -
medchemcomm
Language(s) - English
Resource type - Journals
eISSN - 2040-2511
pISSN - 2040-2503
DOI - 10.1039/c3md00028a
Subject(s) - ec50 , stereochemistry , chemistry , ic50 , human immunodeficiency virus (hiv) , combinatorial chemistry , selectivity , docking (animal) , structure–activity relationship , drug , lead compound , in vitro , pharmacology , biochemistry , virology , biology , medicine , nursing , catalysis
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