Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams | Zendy

Martine Mondon | Zendy; Soo Hur | Zendy; Grishma Vadlamani | Zendy; Prerana Rodrigues | Zendy; Polina Tsybina | Zendy; Antonio Oliver | Zendy; Brian L. Mark | Zendy; David J. Vocadlo | Zendy; Yves Blériot | Zendy

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Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams

Author(s) -

Martine Mondon,

Soo Hur,

Grishma Vadlamani,

Prerana Rodrigues,

Polina Tsybina,

Antonio Oliver,

Brian L. Mark,

David J. Vocadlo,

Yves Blériot

Publication year - 2013

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c3cc46646a

Subject(s) - pseudomonas aeruginosa , microbiology and biotechnology , antibiotics , bacteria , lactam , chemistry , gram negative bacteria , biology , stereochemistry , escherichia coli , biochemistry , gene , genetics

AmpC β-lactamase confers resistance to β-lactam antibiotics in many Gram negative bacteria. Inducible expression of AmpC requires an N-acetylglucosaminidase termed NagZ. Here we describe the synthesis and characterization of hydroxyazepane inhibitors of NagZ. We find that these inhibitors enhance the susceptibility of clinically relevant Pseudomonas aeruginosa to β-lactams.

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