A photoactivatable drug–caged fluorophore conjugate allows direct quantification of intracellular drug transport | Zendy

Sarit S. Agasti | Zendy; Ashley M. Laughney | Zendy; Rainer H. Köhler | Zendy; Ralph Weissleder | Zendy

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A photoactivatable drug–caged fluorophore conjugate allows direct quantification of intracellular drug transport

Author(s) -

Sarit S. Agasti,

Ashley M. Laughney,

Rainer H. Köhler,

Ralph Weissleder

Publication year - 2013

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c3cc46089d

Subject(s) - fluorophore , intracellular , conjugate , chemistry , biophysics , drug , in vivo , drug delivery , fluorescence , mediated transport , intracellular transport , biochemistry , pharmacology , biology , membrane , mathematical analysis , physics , mathematics , microbiology and biotechnology , organic chemistry , quantum mechanics

We report here a method that utilizes a photoactivatable drug-caged fluorophore conjugate to quantify intracellular drug trafficking processes at single cell resolution. Photoactivation is performed in labeled cellular compartments to visualize intracellular drug exchange under physiological conditions, without the need for washing, facilitating its translation into in vivo cancer models.

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