Spatially controlled DNA unzipping by microfluidic interface positioning on a molecule perpendicular to a multicomponent flow | Zendy

Naresh Kumar Mani | Zendy; Sergii Rudiuk | Zendy; Damien Baigl | Zendy

Open Access

Spatially controlled DNA unzipping by microfluidic interface positioning on a molecule perpendicular to a multicomponent flow

Author(s) -

Naresh Kumar Mani,

Sergii Rudiuk,

Damien Baigl

Publication year - 2013

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c3cc44016h

Subject(s) - microfluidics , perpendicular , intramolecular force , molecule , electric field , materials science , chemical physics , dna , flow (mathematics) , nanotechnology , chemistry , mechanics , stereochemistry , physics , biochemistry , geometry , mathematics , organic chemistry , quantum mechanics

A DNA molecule is rotated under a transversal electric field to be perpendicular to a longitudinal, multicomponent microfluidic flow. Positioning the interface allows us to control DNA unzipping with spatio-temporal resolution. This demonstrates that a microfluidic gradient can be applied at the single molecule level for a dynamic intramolecular stimulation.

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