NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound | Zendy

Louise E. Wedlock | Zendy; Matt R. Kilburn | Zendy; Rong Liu | Zendy; Jeremy Shaw | Zendy; Susan J. BernersPrice | Zendy; Nicholas P. Farrell | Zendy

Open Access

NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound

Author(s) -

Louise E. Wedlock,

Matt R. Kilburn,

Rong Liu,

Jeremy Shaw,

Susan J. BernersPrice,

Nicholas P. Farrell

Publication year - 2013

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c3cc42098a

Subject(s) - platinum , chemistry , nanotechnology , combinatorial chemistry , materials science , biochemistry , catalysis

Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of (195)Pt and (15)N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.

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