Switchable delivery of small interfering RNA using a negatively charged pH-responsive polyethylenimine-based polyelectrolyte complex | Zendy

S.Ja Tseng | Zendy; YiFang Zeng | Zendy; Yu-Fan Deng | Zendy; PanChyr Yang | Zendy; JeRuei Liu | Zendy; Ivan M. Kempson | Zendy

Open Access

Switchable delivery of small interfering RNA using a negatively charged pH-responsive polyethylenimine-based polyelectrolyte complex

Author(s) -

S.Ja Tseng,

YiFang Zeng,

Yu-Fan Deng,

PanChyr Yang,

JeRuei Liu,

Ivan M. Kempson

Publication year - 2013

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c3cc00134b

Subject(s) - polyethylenimine , polyelectrolyte , polyethylene glycol , chemistry , small interfering rna , peg ratio , histidine , cationic polymerization , cytotoxicity , rna , copolymer , biophysics , ethylene glycol , combinatorial chemistry , polymer chemistry , polymer , biochemistry , organic chemistry , amino acid , in vitro , transfection , biology , finance , economics , gene

A small interfering RNA (siRNA)-loaded polyelectrolyte constructed with branched polyethylenimine (bPEI) and copolymers, consisting of polyethylene glycol (PEG), histidine (His), and glutamic acid (Glu), was developed in order to provide a tumor acidosis-triggered delivery system with low cytotoxicity.

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