Phase-transfer reagents as C-terminal protecting groups; facile incorporation of free amino acids or peptides into peptide sequences | Zendy

ShuiTein Chen | Zendy; KungTsung Wang | Zendy

Open Access

Phase-transfer reagents as C-terminal protecting groups; facile incorporation of free amino acids or peptides into peptide sequences

Author(s) -

ShuiTein Chen,

KungTsung Wang

Publication year - 1990

Publication title -

journal of the chemical society chemical communications

Language(s) - English

Resource type - Journals

eISSN - 2050-5639

pISSN - 0022-4936

DOI - 10.1039/c39900001045

Subject(s) - reagent , chemistry , protecting group , peptide , peptide synthesis , nucleophile , salt (chemistry) , amino acid , solvent , combinatorial chemistry , phase (matter) , organic solvent , organic synthesis , organic chemistry , stereochemistry , biochemistry , catalysis , alkyl , chemical engineering , engineering

Phase-transfer reagents (basic, neutral, and acidic) can effect temporary protection of carboxy groups by salt formation in C-terminal free amino acids or peptides during peptide synthesis; the use of acidic or neutral phase-transfer reagents as the C-terminal protecting group will not affect the nucleophilicity of the amino group of the salts thus prepared in an organic solvent.

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