Interstrand disulfide crosslinking of DNA bases supports a double nucleotide unpairing mechanism for flap endonucleases | Zendy

Amanda Beddows | Zendy; Nikesh Patel | Zendy; L. David Finger | Zendy; John M. Atack | Zendy; David M. Williams | Zendy; Jane A. Grasby | Zendy

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Interstrand disulfide crosslinking of DNA bases supports a double nucleotide unpairing mechanism for flap endonucleases

Author(s) -

Amanda Beddows,

Nikesh Patel,

L. David Finger,

John M. Atack,

David M. Williams,

Jane A. Grasby

Publication year - 2012

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c2cc33400c

Subject(s) - duplex (building) , nucleotide , dna , disulfide bond , chemistry , thiouracil , hydrolysis , combinatorial chemistry , biochemistry , biology , genetics , thyroid , gene

Flap endonucleases (FENs) are proposed to select their target phosphate diester by unpairing the two terminal nucleotides of duplex. Interstrand disulfide crosslinks, introduced by oxidation of thiouracil and thioguanine bases, abolished the specificity of human FEN1 for hydrolysis one nucleotide into the 5'-duplex.

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