Synthesis and X-ray structure analysis of a heptacoordinate titanium(iv)-bis-chelate with enhanced in vivo antitumor efficacy | Zendy

Timo A. Immel | Zendy; Martin Grützke | Zendy; AnneKatrin Späte | Zendy; Ulrich Groth | Zendy; Peter Öhlschläger | Zendy; Thomas Huhn | Zendy

Open Access

Synthesis and X-ray structure analysis of a heptacoordinate titanium(iv)-bis-chelate with enhanced in vivo antitumor efficacy

Author(s) -

Timo A. Immel,

Martin Grützke,

AnneKatrin Späte,

Ulrich Groth,

Peter Öhlschläger,

Thomas Huhn

Publication year - 2012

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c2cc31624b

Subject(s) - chelation , hela , in vivo , titanium , ligand (biochemistry) , alkoxide , chemistry , aqueous solution , combinatorial chemistry , redox , nuclear chemistry , in vitro , inorganic chemistry , biochemistry , receptor , organic chemistry , biology , catalysis , microbiology and biotechnology

Chelate stabilization of a titanium(IV)-salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.

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