Stepping towards highly flexible aptamers: enzymatic recognition studies of unlocked nucleic acid nucleotides | Zendy

Camille Dubois | Zendy; Meghan A. Campbell | Zendy; Stacey L. Edwards | Zendy; Jesper Wengel | Zendy; Rakesh N. Veedu | Zendy

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Stepping towards highly flexible aptamers: enzymatic recognition studies of unlocked nucleic acid nucleotides

Author(s) -

Camille Dubois,

Meghan A. Campbell,

Stacey L. Edwards,

Jesper Wengel,

Rakesh N. Veedu

Publication year - 2012

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c2cc31316b

Subject(s) - nucleic acid , polymerase , nucleotide , primer (cosmetics) , dna , polymerase chain reaction , primer extension , chemistry , dna polymerase , enzyme , biochemistry , microbiology and biotechnology , biology , gene , organic chemistry

Enzymatic recognition of unlocked nucleic acid (UNA) nucleotides was successfully accomplished. Therminator DNA polymerase was found to be an efficient enzyme in primer extension reactions. Polymerase chain reaction (PCR) amplification of a 81 mer UNA-modified DNA library was efficiently achieved by KOD DNA polymerase.

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