Highly relaxing gadolinium based MRI contrast agents responsive to Mg2+ sensing | Zendy

Sabah Abada | Zendy; Alexandre Lecointre | Zendy; Mourad Elhabiri | Zendy; David EstebanGómez | Zendy; Carlos PlatasIglesias | Zendy; Gaylord Tallec | Zendy; Marinella Mazzanti | Zendy; Loı̈c J. Charbonnière | Zendy

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Highly relaxing gadolinium based MRI contrast agents responsive to Mg2+ sensing

Author(s) -

Sabah Abada,

Alexandre Lecointre,

Mourad Elhabiri,

David EstebanGómez,

Carlos PlatasIglesias,

Gaylord Tallec,

Marinella Mazzanti,

Loı̈c J. Charbonnière

Publication year - 2012

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c2cc30757j

Subject(s) - gadolinium , contrast (vision) , aqueous solution , ligand (biochemistry) , chemistry , mri contrast agent , nuclear magnetic resonance , crystallography , computer science , physics , organic chemistry , receptor , biochemistry , artificial intelligence

A Gd complex based on a polyphosphonated pyridyl ligand shows a very high stability in aqueous solution (log K(EuL) = 25.7), a high relaxivity (8.5 mM(-1) s(-1) at 25 °C and 20 MHz) and a marked and selective relaxivity enhancement (37%) in the presence of Mg(2+), opening interesting perspectives for the design of cation responsive contrast agents.

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