Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors | Zendy

Adam J. Salmon | Zendy; Michael L. Williams | Zendy; Andreas Hofmann | Zendy; SallyAnn Poulsen | Zendy

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Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors

Author(s) -

Adam J. Salmon,

Michael L. Williams,

Andreas Hofmann,

SallyAnn Poulsen

Publication year - 2012

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c2cc15625c

Subject(s) - ruthenocene , ferrocene , carbonic anhydrase , chemistry , enzyme , active site , crystal structure , stereochemistry , combinatorial chemistry , crystallography , biochemistry , electrochemistry , electrode

We have determined the protein X-ray crystal structures of four organometallic inhibitors in complex with their target enzyme carbonic anhydrase II. The barrel-shaped hydrophobic ferrocene and ruthenocene moieties have provided a structure-based avenue to better occupy the hydrophobic binding patch within the enzyme active site.

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