Calcium ions as bioinspired triggers to reversibly control the coil-to-helix transition in peptide-polymer conjugates | Zendy

Romina I. Kühnle | Zendy; Denis Gebauer | Zendy; Hans G. Börner | Zendy

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Calcium ions as bioinspired triggers to reversibly control the coil-to-helix transition in peptide-polymer conjugates

Author(s) -

Romina I. Kühnle,

Denis Gebauer,

Hans G. Börner

Publication year - 2011

Publication title -

soft matter

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 170

eISSN - 1744-6848

pISSN - 1744-683X

DOI - 10.1039/c1sm05625e

Subject(s) - conjugate , peptide , helix (gastropod) , calcium , bioconjugation , chemistry , ion , transition (genetics) , polymer , biophysics , nanotechnology , materials science , crystallography , combinatorial chemistry , biochemistry , organic chemistry , mathematical analysis , ecology , mathematics , snail , gene , biology

Controlling a coil-to-helix transition in peptide–polymer conjugates with soft stimuli requires the careful balancing of stabilizing and destabilizing effects in the peptide segment. The transition between two secondary structures of a bioconjugate is realized using calcium ions to establish a biomimetic control mechanism. Regulation of Ca2+-ion levels via competitive Ca2+-ion binders made the process reversible.

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