A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells | Zendy

Jiří Paleček | Zendy; Robert Zweigerdt | Zendy; Ruth Olmer | Zendy; Ulrich Martin | Zendy; Andreas Kirschning | Zendy; Gerald Dräger | Zendy

Open Access

A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells

Author(s) -

Jiří Paleček,

Robert Zweigerdt,

Ruth Olmer,

Ulrich Martin,

Andreas Kirschning,

Gerald Dräger

Publication year - 2011

Publication title -

organic and biomolecular chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.923

H-Index - 146

eISSN - 1477-0539

pISSN - 1477-0520

DOI - 10.1039/c1ob05332a

Subject(s) - induced pluripotent stem cell , chemistry , kinase , embryonic stem cell , dissociation (chemistry) , stem cell , microbiology and biotechnology , biochemistry , organic chemistry , biology , gene

A practical synthesis of the Rho-Kinase inhibitor Y-27632 and two new fluoro derivatives was achieved in seven steps and with a good overall yield of 45% starting from commercially available (R)-1-phenylethylamine. Compared to Y-27632 the new fluoro derivatives showed reduced or no effect on hPSC vitality and expansion after dissociation in human pluripotent stem cells.

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