Biotransformation of BMOV in the presence of blood serum proteins | Zendy

Daniele Sanna | Zendy; Linda Bíró | Zendy; Péter Buglyó | Zendy; Giovanni Micera | Zendy; Eugenio Garribba | Zendy

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Biotransformation of BMOV in the presence of blood serum proteins

Author(s) -

Daniele Sanna,

Linda Bíró,

Péter Buglyó,

Giovanni Micera,

Eugenio Garribba

Publication year - 2011

Publication title -

metallomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.012

H-Index - 75

eISSN - 1756-591X

pISSN - 1756-5901

DOI - 10.1039/c1mt00161b

Subject(s) - biotransformation , chemistry , in vivo , human blood , blood proteins , biochemistry , enzyme , biology , physiology , microbiology and biotechnology

The interaction of the potent anti-diabetic agent bis(maltolato)oxidovanadium(IV) (BMOV) with some proteins of blood serum was studied by EPR spectroscopy, pH-potentiometry and DFT calculations. The formation of cis-VO(ma)(2)(hTf), cis-VO(ma)(2)(HSA) and cis-VO(ma)(2)(IgG), their role in the biotransformation in vivo and the mechanism of transport of BMOV in blood are discussed.

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