Iron homeostasis and management of oxidative stress response in bacteria | Zendy

Pierre Cornélis | Zendy; Qing Wei | Zendy; Simon C. Andrews | Zendy; Tiffany Vinckx | Zendy

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Iron homeostasis and management of oxidative stress response in bacteria

Author(s) -

Pierre Cornélis,

Qing Wei,

Simon C. Andrews,

Tiffany Vinckx

Publication year - 2011

Publication title -

metallomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.012

H-Index - 75

eISSN - 1756-591X

pISSN - 1756-5901

DOI - 10.1039/c1mt00022e

Subject(s) - oxidative stress , reactive oxygen species , iron homeostasis , bacteria , homeostasis , oxidative phosphorylation , chemistry , microbiology and biotechnology , microorganism , biochemistry , biology , metabolism , genetics

Iron is both an essential nutrient for the growth of microorganisms, as well as a dangerous metal due to its capacity to generate reactive oxygen species (ROS) via the Fenton reaction. For these reasons, bacteria must tightly control the uptake and storage of iron in a manner that restricts the build-up of ROS. Therefore, it is not surprising to find that the control of iron homeostasis and responses to oxidative stress are coordinated. The mechanisms concerned with these processes, and the interactions involved, are the subject of this review.

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