Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells | Zendy

Mihai Ciobanu | Zendy; KuoTing Huang | Zendy; JeanPierre Daguer | Zendy; Sofía Barluenga | Zendy; Olivier Chaloin | Zendy; Evelyne Schaeffer | Zendy; Christopher G. Mueller | Zendy; Daniel A. Mitchell | Zendy; Nicolas Winssinger | Zendy

Open Access

Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells

Author(s) -

Mihai Ciobanu,

KuoTing Huang,

JeanPierre Daguer,

Sofía Barluenga,

Olivier Chaloin,

Evelyne Schaeffer,

Christopher G. Mueller,

Daniel A. Mitchell,

Nicolas Winssinger

Publication year - 2011

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c1cc13213j

Subject(s) - dc sign , dendrimer , glycan , nucleic acid , dna , chemistry , computational biology , combinatorial chemistry , stereochemistry , microbiology and biotechnology , dendritic cell , biochemistry , glycoprotein , biology , genetics , antigen

We report the synthesis of a nucleic acid-encoded carbohydrate library, its combinatorial self-assembly into 37,485 pairs and a screen against DC-SIGN leading to the identification of consensus ligand motifs. A prototypical example from the selected pairs was shown to have enhanced binding. A dendrimer incorporating the selected motifs inhibited gp120's binding to dendritic cells with higher efficiency than mannan.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research