Biocompatible, surface functionalized mesoporous titania nanoparticles for intracellular imaging and anticancer drug delivery | Zendy

Kevin C.W. Wu | Zendy; Yusuke Yamauchi | Zendy; Chen-Yu Hong | Zendy; Ya-Huei Yang | Zendy; Yung-He Liang | Zendy; Takashi Funatsu | Zendy; Makoto Tsunoda | Zendy

Open Access

Biocompatible, surface functionalized mesoporous titania nanoparticles for intracellular imaging and anticancer drug delivery

Author(s) -

Kevin C.W. Wu,

Yusuke Yamauchi,

Chen-Yu Hong,

Ya-Huei Yang,

Yung-He Liang,

Takashi Funatsu,

Makoto Tsunoda

Publication year - 2011

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c1cc10659g

Subject(s) - biocompatibility , doxorubicin , drug delivery , nanoparticle , biocompatible material , intracellular , chemistry , mesoporous material , nanotechnology , surface modification , drug carrier , combinatorial chemistry , biophysics , materials science , organic chemistry , biochemistry , biomedical engineering , catalysis , medicine , surgery , chemotherapy , biology

Mesoporous titania nanoparticles (MTNs) with excellent biocompatibility (LC(50)≈ 400 μg mL(-1)) and a large surface area (ca. 237.3 m(2) g(-1)) were synthesized and further functionalized with a phosphate-containing fluorescent molecule (i.e. flavin mononucleotide; FMN) and loaded with an anticancer drug (i.e. Doxorubicin) for successful intracellular bioimaging and drug delivery, respectively, in human breast cancer cells BT-20.

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