Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives | Zendy

Steven A. Rogers | Zendy; Daniel C. Whitehead | Zendy; Trey Mullikin | Zendy; Christian Melander | Zendy

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Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives

Author(s) -

Steven A. Rogers,

Daniel C. Whitehead,

Trey Mullikin,

Christian Melander

Publication year - 2010

Publication title -

organic and biomolecular chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.923

H-Index - 146

eISSN - 1477-0539

pISSN - 1477-0520

DOI - 10.1039/c0ob00063a

Subject(s) - chemistry , biofilm , carbamate , metabolite , ic50 , ethyl carbamate , combinatorial chemistry , bacteria , microbiology and biotechnology , stereochemistry , biochemistry , in vitro , food science , genetics , wine , biology

An 88 member library based upon the marine bacterial metabolite ethyl N-(2-phenethyl) carbamate was evaluated for bacterial biofilm inhibition against a panel of medically relevant strains. These studies culminated in the discovery of a new class of molecules capable of inhibiting the formation of S. aureus biofilms with low micromolar IC(50) values.

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