Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases | Zendy

Ebany J. MartinezFinley | Zendy; Daiana Silva Ávila | Zendy; Sudipta Chakraborty | Zendy; Michael Aschner | Zendy

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Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases

Author(s) -

Ebany J. MartinezFinley,

Daiana Silva Ávila,

Sudipta Chakraborty,

Michael Aschner

Publication year - 2011

Publication title -

metallomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.012

H-Index - 75

eISSN - 1756-591X

pISSN - 1756-5901

DOI - 10.1039/c0mt00064g

Subject(s) - caenorhabditis elegans , neurodegeneration , disease , neuroscience , biology , parkinson's disease , genetics , medicine , gene , pathology

Neurodegeneration is characterized by the cell death or loss of structure and/or function of neurons. Many neurodegenerative diseases including Parkinson's disease (PD) and Alzheimer's disease (AD) are the result of neurodegenerative processes. Metals are essential for many life processes, but they are also culpable for several neurodegenerative mechanisms. In this review, we discuss the role of metals in neurodegenerative diseases with emphasis on the utility of Caenorhabditis elegans (C. elegans) genetic models in deciphering mechanisms associated with the etiology of PD and AD.

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