Cupredoxins—A study of how proteins may evolve to use metals for bioenergetic processes | Zendy

Moonsung Choi | Zendy; Victor L. Davidson | Zendy

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Cupredoxins—A study of how proteins may evolve to use metals for bioenergetic processes

Author(s) -

Moonsung Choi,

Victor L. Davidson

Publication year - 2011

Publication title -

metallomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.012

H-Index - 75

eISSN - 1756-591X

pISSN - 1756-5901

DOI - 10.1039/c0mt00061b

Subject(s) - bioenergetics , electron transfer , redox , copper protein , electron transport chain , chemistry , function (biology) , mutagenesis , copper , photosynthesis , biophysics , biochemistry , computational biology , biology , microbiology and biotechnology , mitochondrion , mutation , gene , photochemistry , inorganic chemistry , organic chemistry

Cupredoxins are small proteins that contain type I copper centers, which are ubiquitous in nature. They function as electron transfer shuttles between proteins. This review of the structure and properties of native cupredoxins, and those modified by site-directed mutagenesis, illustrates how these proteins may have evolved to specifically bind copper, develop recognition sites for specific redox partners, tune redox potential for a particular function, and allow for efficient electron transfer through the protein matrix. This is relevant to the general understanding of the roles of metals in energy metabolism, respiration and photosynthesis.

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