Open AccessComparison between α- and β-carbonic anhydrases: can Zn(His)3(H2O) and Zn(His)(Cys)2(H2O) sites lead to equivalent enzymes?
Author(s) -
Florent Pannetier,
Gilles Ohanessian,
Gilles Frison
Publication year - 2011
Publication title -
dalton transactions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.98
H-Index - 184
eISSN - 1477-9234
pISSN - 1477-9226
DOI - 10.1039/c0dt01454k
Subject(s) - chemistry , enzyme , zinc , molecule , carbonic anhydrase , coordination sphere , biochemistry , inorganic chemistry , stereochemistry , crystallography , organic chemistry
Large models of α- and β-carbonic anhydrases were compared using DFT calculations. They indicate similar acidity of the coordinated water molecule and zinc affinity. This explains their similar mechanism of action, despite the wide difference in their first coordination sphere.
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