Tetra-end-linked oligonucleotides forming DNA G-quadruplexes: a new class of aptamers showing anti-HIV activity | Zendy

Giorgia Oliviero | Zendy; Jussara Amato | Zendy; Nicola Borbone | Zendy; Stefano D’Errico | Zendy; Aldo Galeone | Zendy; Luciano Mayol | Zendy; Shozeb Haider | Zendy; Olujide O. Olubiyi | Zendy; Bart Hoorelbeke | Zendy; Jan Balzarini | Zendy; Gennaro Piccialli | Zendy

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Tetra-end-linked oligonucleotides forming DNA G-quadruplexes: a new class of aptamers showing anti-HIV activity

Author(s) -

Giorgia Oliviero,

Jussara Amato,

Nicola Borbone,

Stefano D’Errico,

Aldo Galeone,

Luciano Mayol,

Shozeb Haider,

Olujide O. Olubiyi,

Bart Hoorelbeke,

Jan Balzarini,

Gennaro Piccialli

Publication year - 2010

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c0cc02866e

Subject(s) - oligonucleotide , aptamer , dna , tetra , chemistry , combinatorial chemistry , human immunodeficiency virus (hiv) , g quadruplex , computational biology , biology , genetics , virology , biochemistry , medicinal chemistry

The biophysical and biological properties of unprecedented anti-HIV aptamers are presented. The most active aptamer (1L) shows a significant affinity to the HIV protein gp120.

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