Multiphoton microscopy of transdermal quantum dot delivery using two photonpolymerization-fabricated polymer microneedles | Zendy

Shaun D. Gittard | Zendy; Philip Miller | Zendy; Ryan D. Boehm | Zendy; Aleksandr Ovsianikov | Zendy; Boris N. Chichkov | Zendy; Jeremy Heiser | Zendy; John Gordon | Zendy; Nancy A. MonteiroRiviere | Zendy; Roger J. Narayan | Zendy

Open Access

Multiphoton microscopy of transdermal quantum dot delivery using two photonpolymerization-fabricated polymer microneedles

Author(s) -

Shaun D. Gittard,

Philip Miller,

Ryan D. Boehm,

Aleksandr Ovsianikov,

Boris N. Chichkov,

Jeremy Heiser,

John Gordon,

Nancy A. MonteiroRiviere,

Roger J. Narayan

Publication year - 2010

Publication title -

faraday discussions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.255

H-Index - 110

eISSN - 1364-5498

pISSN - 1359-6640

DOI - 10.1039/c005374k

Subject(s) - transdermal , quantum dot , materials science , nanotechnology , polymer , microscopy , drug delivery , two photon excitation microscopy , human skin , polymerization , biomedical engineering , optoelectronics , optics , composite material , fluorescence , medicine , pathology , physics , pharmacology , biology , genetics

Due to their ability to serve as fluorophores and drug delivery vehicles, quantum dots are a powerful tool for theranostics-based clinical applications. In this study, microneedle devices for transdermal drug delivery were fabricated by means of two-photon polymerization of an acrylate-based polymer. We examined proliferation of cells on this polymer using neonatal human epidermal keratinocytes and human dermal fibroblasts. The microneedle device was used to inject quantum dots into porcine skin; imaging of the quantum dots was performed using multiphoton microscopy.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research