Label-free DNA detection platform based on atomic force microscopy visualisation: characterising the molecular-recognition-triggered conformational changes of an immobilised receptor oligonucleotide probe | Zendy

Koji Nakano | Zendy; Hirokazu Yamanouchi | Zendy; Hisao Yoshinaga | Zendy; Nobuaki Soh | Zendy; Toshihiko Imato | Zendy

Open Access

Label-free DNA detection platform based on atomic force microscopy visualisation: characterising the molecular-recognition-triggered conformational changes of an immobilised receptor oligonucleotide probe

Author(s) -

Koji Nakano,

Hirokazu Yamanouchi,

Hisao Yoshinaga,

Nobuaki Soh,

Toshihiko Imato

Publication year - 2010

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c002642e

Subject(s) - oligonucleotide , dna , atomic force microscopy , chemistry , molecular recognition , helix (gastropod) , biophysics , microscopy , nanotechnology , a dna , crystallography , materials science , molecule , biochemistry , biology , physics , ecology , organic chemistry , snail , optics

Using atomic microscopy imaging, probe DNA sequence self-assemblies developed on Si(100) substrates undergo a conformational transition from an extended stem-loop structure to a double helix; such assemblies readily report on DNA molecular recognition events and should be suitable as a label-free, DNA hybridisation assay platform.

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